ABSTRACT
In present agricultural practices greenhouse gases are created in a multitude of ways. Pesticide and fertilizer applications, irrigation, lighting, transportation, and other machinery are powered by greenhouse gas-emitting fossil fuels. The fertilizers and pesticides alone are one of the largest contributors to greenhouse gas emissions in agriculture. The overuse of agricultural chemicals pollutes watersheds and kills plants that could otherwise capture greenhouse gases and actually reduce global warming. Compared to conventional agriculture, organic agriculture is reported to be more efficient and effective both in reducing GHGs (CO2, CH4 and N2O) emission mainly due to the less use of chemical fertilizers and pesticides. Organic agriculture also reported to be climate change resilience farming systems as it promotes the proper management of soil, water, biodiversity and local knowledge there by acting as a good options for adaptation to climate change. In the present study two of the cucurbits are studied for their insecticidal acitivity against Aphids one is a wild specie Citrullus colocynthis (Linn.) Schrad.and another one is cultivated specie that is Luffa acutangula (L.) Roxb., both have found effective but C. colocynthis found more effective than L. Acutangula.
ABSTRACT
The present study reports protective effect of hydro-alcoholic extract of Luffa acutangula (HAELA) on doxorubicin (DXR) induced cardio and nephro toxicity in mice by studying various serum biomarkers, antioxidants in target organs and histoarchitecture alterations. Pretreatment with HAELA reversed significantly the elevated serum biomarkers, alanine amino transferase, lactate dehydrogenase and creatinine phosphokinase in heart and kidney in DXR treated mice. In addition, HAELA treatment inhibited elevated malondialdehyde formation and restored the depleted glutathione, catalase, superoxide dismutase in heart and kidney tissue. The altered histoarchitecture of heart and kidney tissue due to DXR treatment were also improved with HAELA. The protective activity observed with HAELA on DXR induced cardio and nephrotoxicity in mice was found to be related to its antioxidant property which finally results in membrane stabilization.
Subject(s)
Administration, Oral , Animals , Antioxidants/metabolism , Biomarkers/blood , Cardiovascular Diseases/blood , Cardiovascular Diseases/drug therapy , Doxorubicin , Female , Kidney/drug effects , Kidney/pathology , Kidney Diseases/blood , Kidney Diseases/drug therapy , Luffa/chemistry , Male , Mice , Myocardium/pathology , Phytotherapy , Plant Extracts/administration & dosage , Plant Extracts/pharmacology , Plant Extracts/therapeutic use , Staining and Labeling , Toxicity Tests, AcuteABSTRACT
Hepatoprotective activity of hydroalcoholic extract of Luffa acutangula (HAELA) against carbon tetrachloride (CCl4) and rifampicin-induced hepatotoxicity in rats was evaluated and probable mechanism(s) of action has been suggested. Administration of standard drug- silymarin and HAELA showed significant hepatoprotection against CCl4 and rifampicin induced hepatotoxicity in rats. Hepatoprotective activity of HAELA was due to the decreased levels of serum marker enzymes viz., (AST, ALT, ALP and LDH) and increased total protein including the improvement in histoarchitecture of liver cells of the treated groups as compared to the control group. HAELA also showed significant decrease in malondialdehyde (MDA) formation, increased activity of non-enzymatic intracellular antioxidant, glutathione and enzymatic antioxidants, catalase and superoxide dismutase. Results of this study demonstrated that endogenous antioxidants and inhibition of lipid peroxidation of membrane contribute to hepatoprotective activity of HAELA.